The Cognitive-Interpersonal Maintenance Model of Anorexia Nervosa Revisited: A summary of the evidence for cognitive, socio-emotional and interpersonal predisposing and perpetuating factors.

Authors: Treasure, J., Schmidt, U.
Literature review trying to identify pre-morbid tendencies that might contribute to the onset and maintenance of restrictive eating disorders. OCD, weak set shifting ability, attention bias towards critical and domineering faces, impaired regulation and interpretation of emotion and difficulties in social cognition. Too early to identify how these things might be applied to better treatments obviously [site owner comment].

 

Quinolinic Acid: Suicide Attempts Linked To Chemical's Presence In Spinal Fluid, Study Says

Authors: Pappas, S.
Brief mainstream article on research from L. Brundin et. al., on the link between inflammation and suicidality. Quinolininc acid, a compound associated with inflammation. The higher CSF presence of quinolinic acid appeared to correlate to suicide attempt. Itappears that quinolinic acid mimics glutamate function within the brain. Its an intriguing avenue for future study.

 

The Genetic and Epigenetic Basis of Type 2 Diabetes and Obesity

Authors: Drong, A.W., Lindgren, C.M., McCarthy, M.I.
To date, more than 150 genetic loci are associated with the development of monogenic, syndromic, or multifactorial forms of T2D or obesity. However, the proportion of overall trait variance explained by these associated loci is modest (~5–10% for T2D, ~2% for body mass index (BMI)). Some of the familial aggregation not attributable to known genetic variation, as well as many of the effects of environmental exposures, may reflect epigenetic processes.

 

Food restriction-induced hyperactivity: Addiction or adaptation to famine?

Authors: Dulcos, M., Ouerdani, A., Mormède, P., Konsman, J.P.
Rat study. A nifty little study (we are not rats of course) that indicates the exposure to sucrose eases the fleeing-famine-like hyperactivity response [see S. Guisinger articles in references for further details on fleeing famine and AN). Complete supposition, but perhaps the predilection for sweet in early phases of recovery for patients with restrictive eating disorders might be have additional value in easing and lessening the hyperactivity that exacerbates the continual pattern of energy deficits [site owner comment].