Association of the 5-HT2c gene with susceptibility and minimum body mass index in anorexia nervosa

Authors: Hu, X., Giotakis, O., Li, T., Karawautz, A., Treasure, J., Collier, D.A.
"There was significant correlation between genotype and minimum BMI (r2 = 0.056; p = 0.01), indicating that the Ser23 allele has an effect on severity of illness. We performed TDT analysis using a sub-sample of the cases (58) for whom both parents were available and we found an excess transmission of the Ser23 allele (p = 0.05). Our findings are consistent a role for the Ser23 allele of 5-HT2c in mediating susceptibility to and increasing severity of anorexia nervosa."