The Genetic and Epigenetic Basis of Type 2 Diabetes and Obesity

Authors: Drong, A.W., Lindgren, C.M., McCarthy, M.I.
To date, more than 150 genetic loci are associated with the development of monogenic, syndromic, or multifactorial forms of T2D or obesity. However, the proportion of overall trait variance explained by these associated loci is modest (~5–10% for T2D, ~2% for body mass index (BMI)). Some of the familial aggregation not attributable to known genetic variation, as well as many of the effects of environmental exposures, may reflect epigenetic processes.